Study on the correlation between systolic blood pressure classification and neutrophils and lymphocytes in systolic

Shi Jingjing; Wang Huan; Hu Yuanhui; Qiu Zhiling; Bo Rongqiang; Feng Rui; Chu Yuguang; Wei Yi

doi:10.3969/j.issn.1674-4055.2017.09.15

Abstract：Objective To study the relationship between pulse pressure and neutrophils and lymphocytes in patients with simple systolic hypertension. Methods 415 patients with simple systolic hypertension were enrolled. The general condition, history, height, weight, BMI, blood pressure and so on were measured. According to the pulse pressure level, patients were divided into three groups: group one (50 mmHg≤pulse pressure <70 mmHg, n=122); group two (70 mmHg≤pulse pressure <90 mmHg, n=136); group three (90 mmHg≤pulse pressure <110 mmHg, n=40). The levels of neutrophils (NEU) and percentage (NEU%), lymphocyte count (LYM) and percentage (LYM%) and neutrophil / lymphocyte (NLR) were compared. Results The lymphocyte count and percentage showed a decreasing trend in the order of group 1, group 2 and group 3. The neutrophil count and percentage showed a gradual increase trend in the order of group 1, group 2 and group 3. The NLR showed a increase trend in the order of group 1, group 2 and group 3. With respect of indicators above, there were significant differences between group 2 or group3 and group 1 (P<0.05). Result of correlation analysis showed a significant negative correlation between pulse pressure and lymphocyte count (r=-0.137, P=0.018), percentage of lymphocytes (r=-0.206, P<0.001); and neutrophil count (r=0.135, P=0.02), neutrophil percentage (r=0.335, P<0.001), and NLR (r=0.189, P=0.001). Conclusion Increased neutrophil and lymphocyte counts were associated with increased pulse pressure. Increased pulse pressure was associated with adverse cardiovascular events. NLR could better reflect the level of inflammation and high levels of NLR may be associated with increased cardiovascular risk.