Features of adverse reactions after treatment with angiotensin converting enzyme inhibitor
Xu Chaofei
Abstract：Objective To analyze the features of adverse reactions after treatment with angiotensin converting enzyme inhibitor (ACEI).Methods The patients (n=412, male 243, female 169, aged from 18 to 75 and average age=52.5±4.9) with adverse reactions after treatment with ACEI were chosen from the Department of Cardiology in Gaoyou Hospital of Chinese Medicine from May 2011 to May 2016. The age, drug administration, manifestations and occurrence time of adverse reactions and treatment conditions were retrospectively analyzed in all patients.Results The percentages of patients aged<30 and from 30 to 39 were lower, and patients' ages mainly distributed from 40 to 49, 50 to 59, 60 to 69 and over 70. The proportion of adverse reactions induced by captopril was the highest (77.91％), and that by benazepril was 8.74％ and by enalapril was 7.04％. The proportions of adverse reactions induced by ramipril (2.91％), fosinopril (1.46％), perindopril (1.46％) and lisinopril (0.49％) were lower. The clinical manifestations of adverse reactions induced by ACEI were mainly wheezing, coughing and throat discomfort, and mainly involved the respiratory system, accounting for 65.05％. The adverse reactions involved skin in 7.77％ of patients, and clinical manifestations included rash, edema, inflammation and ulcer. The adverse reactions involved the urogenital system in 7.77％ of patients, and clinical manifestations included frequent urination, proteinuria and hematuresis, and involved the cardiovascular system in 7.04％ of patients, blood system in 4.85％, digestive system in 4.85％, and joints and muscle in 2.18％. Among 412 patients, there were 26 (6.31％) with adverse reactions at medication day and 386 (93.69％) with adverse reactions after 2 d, and the average time was (16.9±10.4) d. The symptoms of adverse reactions were relieved and disappeared in the most of patients after treatment or stopping medication, while there were 30 patients had the same adverse reactions after re-medication. Conclusion The manifestations of adverse reactions induced by ACEI are multiple and causes are complex, which will disappear after symptomatic treatment or stopping medication. The adverse reactions should be closely monitored in clinic for improving safety of medication.
Keywords：Angiotensin converting enzyme inhibitorDepartment of cardiologyAdverse reactionsRational drug administration
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 969-971 )