Effects of levosimendan on cardiac function and N-terminal pro-brain natriuretic peptide in patients with refractory heart failure
Wang Shaojun
Wang Xuezhong
Zhang Xianlin
Wang Yuesong
Zhang Ping
Abstract：Objective To investigate the effects of levosimendan on cardiac function and N-terminal pro-brain natriuretic peptide (NT-proBNP) in patients with refractory heart failure.Methods A total of 72 patients with refractory heart failure were chosen from August 2014 to July 2014, and divided into observation group and control group. Control group were treated with conventional treatment, observation group were given levosimendan injection for treatment on the basis of control group. Before and after treatment, patients with cardiac function index and the NT - proBNP level improvement were measured. Clinical curative effect and adverse reaction were compared. Results After treatment, left ventricular end-diastolic diameter (LVEDD) of observation group was significantly lower than that of control group [(62.43±2.31) mmvs. (66.45 ±3.21) mm]. Left ventricular ejection fraction (LVEF) and cardiac index (CI), stroke volume (SV) were significantly higher than the control group [(41.02±4.45)％vs. (37.24±4.24) ％, (2.91±0.45) L·min-1·m-2vs. (2.48±0.38) L·min-1·m-2, (49.21±5.32) mlvs. (44.32 ±4.45)], the difference had statistical significance (P<0.05). NT-proBNP of observation group was significantly lower than that of control group (3532.14±64.32 ng/Lvs. (5321.55±93.53 ng/L] (P<0.05). Total effectiveness in observation group was significantly higher than that in control group [91.67％ (33/36)vs. 66.67％ (24/36)] (P<0.05). There was no significant difference between the observation group and the control group in the adverse reaction rate [5.56％ (2/36)vs. 8.33％ (3/36)] (χ2= 0.2149,P>0.2149).Conclusion Levosimendan can effectively improve cardiac function in patients with refractory heart failure and N - terminal level of b-type natriuretic peptide precursor, clinical curative effect is significant, and high safety.
Keywords：LevosimendanHeart failureCardiac functionN-terminal pro-brain natriuretic peptide
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 944-946 )