Study on correlation between vitamin D deficiency with coronary heart disease and inflammatory markers
Jiang Ling
Shen Xuebin
Ye Guiyun
Huang Qilei
Chen Sheng
Abstract：Objective To investigate the correlation between vitamin D deficiency and coronary heart disease and expression of inflammatory factors.Methods 400 patients received coronary angiography were selected as the research object from June 2014 to June 2016. They were divided into coronary group (n=294) and control group (n=106) according to angiography results. The coronary group included single vessel group with 104 patients, double vessel group with 98 patients and three vessel group with 94 patients. The expression level of serum 25- hydroxy vitamin D (25-OHD) were measured and compared. The expression level of interleukin-6 (IL-6), interleukin-10 (IL-10) and high sensitive C reactive protein (hs-CRP) were measured and compared. The expression levels of Total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C),three acyl glycerol (TG) and fasting plasma glucose (FPG) were measured and compared. The correlation between 25-OHD and biochemical indexes were analyzed.Results The expression of 25-OHD of single vessel group, double vessel group and three vessel group was less than or equal to 20 ng/dl and was significantly lower than that of control group (P<0.01). The expressions of IL-6, IL-10 and hs-CRP of single vessel group, double vessel group and three vessel group were significantly higher than those of control group's (P<0.05). The expressions of TC, LDL-C, TG and FPG of three groups above were significantly higher than those of control group (P<0.01). The expressions of HDL-C of three groups above were significantly lower than that of control group (P<0.05). The expression of 25-OHD had a negative correlation with expression level of IL-6, IL-10, TC, TG and hs-CRP in the single vessel group (P<0.05). There were negative correlations between 25-OHD with IL-6, IL-10, TC, TG ,hs-CRP, FPG, and LDL-C (P<0.05), and there was a positive correlation between 25-OHD with HDL-C in double vessel group and three vessel group (P<0.05). IL-6, IL-10, TC, TG, hs-CRP, HDL-C and LDL-C were the influencing factors of vitamin D deficiency (P<0.05).Conclusion Vitamin D deficiency and coronary heart disease and blood inflammation factors are related.
Keywords：Vitamin D deficiencyCoronary heart diseaseInflammatory factorsCorrelation
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 937-940 )