Influence of salvianolate on hemodynamics and hemorrheology in rats with atherosclerosis
Meng Xiangru
Zhang Zhen
Wang Hongwei
Lv Ping
Abstract：Objective To analyze the influence of salvianolate on hemodynamics and hemorrheology in rats with atherosclerosis.Methods SD rats (n=96) were randomly divided into normal control group, model group, low-dose salvianolate group [60 mg/(kg·d)], mid-dose salvianolate group [120 mg/(kg·d)], high-dose salvianolate group [240 mg/(kg·d)] and simvatatin group [2 mg/(kg·d), eachn=16]. The rat model of atherosclerosis was established through feeding high-fat forage and intraperitoneally injecting VD3, and successful model was determined by using ultrasound examination. The salvianolate groups and simvatatin group were respectively given corresponding drugs orally, and meanwhile normal control group and model group were given normal saline in the same volume for 12 weeks. The changes of lv+dp/dtmax, t-dp/dtmax, whole blood viscosity (WBV, high, medium and low share rates), plasma viscosity, hematocrit (Hct) and platelet adhesiveness rate were detected respectively. The indexes of blood fat were detected, including total cholesterol (TC), triglyceride (TG), low-density lipoprotein-cholesterol (LDL-C) and high-density lipoprotein-cholesterol (HDL-C). The aortic morphological structure was observed through HE staining and lesions were graded.Results The level of lv+dp/dtmax decreased significantly and level of t-dp/dtmax increased significantly in model group compared with normal control group (all P<0.01). The level of lv+dp/dtmax increased and level of t-dp/dtmax decreased in mid-dose salvianolate group and high-dose salvianolate group compared with model group (allP<0.05). The indexes of WBV (high, medium and low share rates), plasma viscosity, Hct and platelet adhesiveness rate increased significantly in model group compared with normal control group (all P<0.05). The indexes of plasma viscosity and Hct decreased significantly in mid-dose salvianolate group and high-dose salvianolate group, and WBV (high, medium and low share rates) and platelet adhesiveness rate decreased significantly in high-dose salvianolate group compared with model group (all P<0.05). The levels of TC, TG and LDL-C increased significantly, and level of HDL-C decreased significantly in model group compared with normal control group (all P<0.05). The levels of TC, TG and LDL-C decreased significantly in mid-dose salvianolate group and high-dose salvianolate group, and level of HDL-C increased significantly in high-dose salvianolate group compared with model group (all P<0.05). The results of lesion grading showed that there were 14 rats (87.5％) with grade 2 or higher aortic lesions in model group. The lesion grading was 0 in normal control group, and there were 12 rats (75.0％) with grade 2 or lower aortic lesions in high-dose salvianolate group. Conclusion Salvianolate in high or medium doses can play a protective role through significantly improving the indexes of hemodynamics and hemorrheology in rats with atherosclerosis.
Keywords：SalvianolateAtherosclerosisHemodynamicsHemorrheologyBlood fatRats
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 920-923 )