Gene polymorphism of MTHFR and curative effect of Enalapril Maleate-Folate Tablets
Xia Hongying
Zhang Tiling
Wang Yang
Huang Banghua
Li Zhongkun
Wang Lijun
Liang Yueqin
Abstract：Objective To analyze the correlation between the gene polymorphism of methylenetetrahydrofolate reductase (MTHFR) and curative effect of Enalapril Maleate-Folate Tablets in treatment of H-type hypertension. Methods The patients with H-type hypertension (n=168, male 84 and female 84) were chosen from the Department of Cardiology of Yan'an Hospital affiliated to Kunming Medical University from Oct. 2013 to Sept. 2015. All patients were randomly divided into observation group (n=85) and control group (n=83). The control group was given Enalapril Tablets and observation group was given Enalapril Maleate-Folate Tablets for one therapeutic course (4 weeks). The genotypes of MTHFR were measured in all selectees before treatment, and the levels of plasma homocysteine (Hcy) and blood pressure (BP) were detected before and 4 weeks after treatment.Results The levels of BP and Hcy decreased significantly in 2 groups after treatment, and the decrease was more significant in observation group (all P<0.05). The genotypes of MTHFR were CC, CT and TT in the patients in 2 groups, and the comparison in genotype frequency showed that the difference had no statistical significance between 2 groups (all P>0.05). After treatment for 4 weeks, the level of Hcy decreased in patients with genotypes of CC, CT and TT in observation group compared with the patients in control group (all P<0.05). The comparison in Hcy level among genotypes of CC, CT and TT in patients in observation group showed that the difference had no statistical significance (all P>0.05).Conclusion Enalapril Maleate-Folate Tablets can obviously improve the levels of BP and Hcy, and its curative effect is better than that of single Enalapril Tablets in patients with H-type hypertension. The curative effect has no significant difference among patients with different genotypes of MTHFR. As the sample size is small in this study, the study with larger sample size is needed to further verify the conclusion.
Keywords：Methylenetetrahydrofolate reductaseGene polymorphismEnalapril Maleate-Folate TabletsH-type hypertensionCurative effect
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 917-919 )