PET/CT imaging study of rabbit abdominal aortic aneurysm with different progression rate
Li Xinhe
Zhao Quanming
Nie Maoxiao
Yan Yunfeng
Feng Tingting
Zhao Xin
Zhang Xuehui
Abstract：Objective To explore the role of PET/CT in assessment of abdominal aortic aneurysm (AAA) progress.Methods We selected 30 New Zealand male rabbits, randomly classified them into 2 groups: the AAA group (group A,n=15) and the hypertension AAA group (group B,n=15). Both two groups are perfused with high elastic protease (100 iu/ml) to establish AAA model. Group B is injected angiotensin Ⅱ(AngⅡ) sequentialy after the surgery. The boold pressure and development of AAA were monitored, Serum monocyte chemoattractant protein (MCP-1), matrix metalloproteinase (MMP9, MMP2) and mean standardized uptake value (SUVmean) of two week-PET/CT scans for both groups were analyzed. Pathological staining (HE,EVG and masson), CD68, MMP9 through immunohistochemical were measured.Results Compared with group A, the blood pressure of rabbits in group B was significantly higher than that in group A. At 14 days postoperatively, the aneurysm growth rate in group B was significantly faster than that in group A. The levels of serum MMP9, MMP2, immunohistochemistry CD68 and MMP9 in group B were all increased, the difference was statistically significant (P<0.01). There was no significant difference in serum MCP-1 between the two groups. Pathological results showed that the level of arterial wall tissue in group A was more turbulence, the elastic fibers were thinner, broken, fragmented and vacuolated, collagen fibers increased; the pathologic changes in group B were more serious. Compared with group A, the number of SUVmean in group B was significantly higher than that in group A (P<0.01). There was a positive correlation between SUVmean and macrophage positive density (IOD) (r=0.751,P<0.01) and MMP9 IOD (r=0.597,P<0.05).Conclusions PET/CT can detect inflammatory infiltration of local lumen and assess the advance rate of AAA of AAA by SUVmean.
Keywords：PET/CTAbdominal aortic aneurysmRabbit modelRate of progress
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 912-916 )