Clinical significance of detection of serum cystatin C combining homocysteine in patients with early renal damage induced by primary hypertension
Cao Yunhe
Dong Xiaofei
Abstract：Objective To investigate the clinical significance of detection of serum cystatin C (Cys C) combining homocysteine (Hcy) in patients with early renal damage induced by primary hypertension.Methods The patients with primary hypertension (n=120, male 71 and female 49) were chosen from the People's Hospital of Juye County from Feb. 2015 to Aug. 2016. The patients with glomerular filtration rate (GFR)≥80 ml/(min·1.73 m2) were chosen into hypertension group (n=62), those with GFR<80 ml/(min·1.73 m2), into early renal damage group (n=58), and the same term health controls, into health group (n=60). The levels of Cys C and Hcy were detected when patients hospitalized and health controls with physical examinations. GFR was detected in all groups at hospitalization time. The early renal damage could be diagnosed when Cys C>1.1 mg/L and Hcy>15 μmol/L. Results The levels of Cys C and Hcy showed an ascending trend in all 3 groups (all P<0.05). The positive rate of single Cys C detection or single Hcy detection was lower than that of detection of Cys C combining Hcy (69.0% vs. 94.8%; 63.8% vs. 94.8%, all P<0.05). GFR was negatively correlated to the levels of serum Cys C and Hcy (r=-0.576;r=-0.341, all P<0.05) in patients with early renal damage induced by primary hypertension.Conclusion The combined detection of Cys C and Hcy is beneficial to the diagnosis of early renal damage induced by primary hypertension, and can be used for guiding clinical treatment.
Keywords：Primary hypertensionEarly renal damageSerum cystatin CHomocysteine
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 854-855,858 )