Correlation between non-alcoholic fatty liver disease and in-stent restenosis after percutaneous coronary intervention
Hu Sheng
Pan Qinghua
Qu Bing
Qian Cheng
Chen Pengfei
Abstract：Objective To discuss the relationship between non-alcoholic fatty liver disease (NAFLD) and in-stent restenosis (ISR) after percutaneous coronary intervention (PCI).Methods The patients with coronary heart disease (CHD,n=277, male 187, female 90 and average age=62.9±8.3), undergone successful PCI and received coronary angiography (CAG) after PCI for 1 y, were chosen from the Central Hospital of Enshi Autonomous Prefecture and Zhongnan Hospital of Wuhan University from Jan. 2013 to Dec. 2015. When the degree of ISR≥50%, ISR was defined, and according to which all patients were divided into ISR group (n=48) and non-ISR group (n=229). The general clinical data, outcomes of laboratory tests, and data of coronary lesions and stent implantation were collected and analyzed.Results The levels of body mass index (BMI), uric acid (UA) and low-density lipoprotein-cholesterol (LDL-C), and percentage of patients with type 2 diabetes mellitus (T2DM) were significantly higher in ISR group than those in non-ISR group (allP<0.05). The length of stent was longer, and diameter of stent was less in ISR group than those in non-ISR group (allP<0.05). The results of Logistic regression analysis showed that NAFLD (OR=2.34, 95%CI: 1.25~4.38), T2DM (R=2.61, 95%CI: 1.32~5.18), UA (OR=1.08, 95%CI:1.01~1.16) and diameter of stent (OR=0.64, 95%CI: 0.48~0.85) were independent influence factors of ISR after PCI. Conclusion NAFLD is closely correlated to ISR, and it is an independent risk factor of ISR after PCI.
Keywords：Non-alcoholic fatty liver diseaseCoronary heart disease (CHD)Drug-eluting stentsIn-stent restenosis
Publication Date：2017-01-01
Pages：3( 828-830 )