Level of serum high-sensitivity cardiac troponin T and early diagnosis of acute myocardial infarction
Lu Zhangqiang
Abstract：Objective To investigate the value of level of serum high-sensitivity cardiac troponin T (hs-cTnT) to the early diagnosis of acute myocardial infarction (AMI).Methods AMI patients (n=80) were chosen into AMI group (hospitalized within 6 h after AMI onset), and patients with chronic heart failure (CHF,n=40) were chosen into CHF group, and health controls (n=40) were chosen into control group from the Second Hospital of Deyang City from Mar. 2016 to Mar. 2017. The levels of serum hs-cTnT, myoglobin (MYO), cardiac troponin T (cTnT) and creatine kinase-M B isoenzyme (CK-MB) were detected in 3 groups. The value of hs-cTnT to AMI diagnosis was analyzed.Results The levels of serum hs-cTnT, MYO, cTnT and CK-MB were significantly higher in AMI group than those in CHF and control group (all P<0.05). The level of serum hs-cTnT was significantly correlated to MYO, cTnT and CK-MB (r=0.479, 0.714, 0.520, all P<0.05). The level of serum hs-cTnT was detected within 6 h after AMI onset and receiver operating characteristic curve (ROC) was drawn. When the best critical value of serum hs-cTnT was 0.050 ng/mL, the sensitivity was 98.96%, specificity was 97.33%, omission diagnostic rate was 1.04%, the misdiagnosis rate was 2.67%, and area under curve (AUC) of ROC was 0.969.Conclusion hs-cTnT has higher sensitivity and specificity in early diagnosis of AMI.
Keywords：High-sensitivity cardiac troponin TEarly diagnosisAcute myocardial infarction
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 817-818,821 )