Predictive value of elevation of high-sensitivity cardiac troponin T to major adverse cardiovascular events in patients with unstable angina pectoris after percutaneous coronary intervention
Zhao Shaopan
Fu Shihui
Luo Leiming
Abstract：Objective To investigate the influence factors on elevation of high-sensitivity cardiac troponin T (hs-cTnT) in patients with unstable angina pectoris (UAP) after percutaneous coronary intervention (PCI), and its predictive effect on major adverse cardiovascular events (MACE) within 1 y after PCI.Methods UAP patients (n=174, male 115 and female 59) undergone PCI were chosen from the Department of Cardiology of Chinese PLA General Hospital from Aug. 2015 to Oct 2015, and divided, according to hs-cTnT changes after PCI, into elevation group (increased>0.1 ng/mL,n=35) and normal group (n=139). The level of baseline data was compared between 2 groups, and influence factors on hs-cTnT elevation were analyzed. The incidence status of MACE was followed up in all patients after PCI for 1 y, and predictive effect of hs-cTnT elevation on MACE was analyzed.Results The level of blood pressure increased and hs-cTnT and N-terminal pro-brain natriuretic peptide (NT-proBNP) decreased in normal group compared with elevation group (all P<0.05). The results of Logistic regression model analysis showed that NT-proBNP (OR=1.001, 95%CI: 1.001~1.002) was an independent risk factor of hs-cTnT elevation, and systolic blood pressure (SBP,OR=0.967, 95%CI: 0.941~0.994) and diastolic blood pressure (DBP, OR=0.951, 95%CI: 0.906~0.999) were protective factors. The incidence rates of target vessel revascularization, stroke and MACE increased significantly in elevation group compared with normal group (8.6% vs. 0.7%; 5.7% vs. 0.7%; 20.0% vs. 5.0%, all P<0.05). The result of Kaplan-Meier survival analysis showed that incidence of MACE was significantly higher in elevation group than that in normal group within 1 y after PCI. The result of COX regression model analysis showed that hs-cTnT elevation was an independent risk factor of MACE (HR=6.303, 95%CI: 2.106~18.862) after revising factors of sex, age, body mass index, heart rate, blood pressure, fasting plasma glucose, creatinine, triglyceride, low-density lipoprotein-cholesterol, and preoperative hs-cTnT and NT-proBNP. Conclusion The elevation of hs-cTnT is correlated to preoperative levels of NT-proBNP, SBP and DBP, and increases significantly the risk of MACE in UAP patients after PCI.
Keywords：Unstable angina pectorisPercutaneous coronary interventionMyocardial enzymeMajor adverse cardiovascular events
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 813-816 )