Influence of salidroside on rats with diabetic cardiomyopathy
GAO Jing-yuan
YANG Yu-yang
XING Lei
LI Ji-an
Abstract：Objective To analyze the influence of salidroside on rats with diabetic cardiomyopathy (DCM). Methods Male SD rats (n=60) were chosen, and 10 were included into control group. After DCM model was successfully established in 40 rats, they were randomly divided into DCM group, low-dose salidroside group (50 mg/kg), mid-dose salidroside group (100 mg/kg) and high-dose salidroside group (200 mg/kg, eachn=10). All salidroside groups were given orally salidroside in corresponding dose and DCM group was given water in the same dose for 12 wk continuously. The levels of interleukin-6 (IL-6) and angiotensin Ⅱ (Ang Ⅱ) were detected after 12 wk. The samples of myocardial tissue were collected for making sections (4 μm), and then the morphological changes of myocardial cells were observed by using light microscope after HE staining.Results The level of serum IL-6 increased significantly in DCM group and all salidroside groups compared with control group (all P<0.05). As the dose of salidroside increased, level of IL-6 decreased gradually, while the difference between mid-dose salidroside group and high-dose salidroside group had no statistical significance (P>0.05). The level of serum Ang-Ⅱ increased significantly in DCM group and all salidroside groups compared with control group (all P<0.05). As the dose of salidroside increased, level of Ang-Ⅱ decreased significantly in all salidroside groups compared with DCM group, showed a dose dependency, and the difference had statistical significance among all groups except of low-dose salidroside group (all P<0.05). The results of HE staining showed that structure of myocardial tissue was disorder, and serious splinter and focal hemorrhage and necrosis and neutrophil aggregation were observed in DCM group. The structure of myocardial tissue was disorder, and splinter and focal hemorrhage and necrosis and serious neutrophil aggregation were observed in low-dose salidroside group. Only mild punctuate hemorrhage and necrosis and neutrophil aggregation were observed in mid-dose and high-dose salidroside groups.Conclusion Salidroside can reduce significantly the levels of serum IL-6 and Ang Ⅱ, relieve myocardial damage and has myocardial protective effect in rats with DCM.
Keywords：SalidrosideDiabetic cardiomyopathyInterleukin-6Angiotensin Ⅱ
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 810-812 )