Correlation between Cys-C,β2-MG levels and left ventricular structure and function in patients with coronary heart disease
YANG Guang
YAO Xiao-wei
LIANG Lei
DENG Ji-zhao
YAN Li
WANG Yi
PAN Jun-qiang
Abstract：Objective To investigate the relationship between serum Cystatin C (Cys-C) and β2-microglobulin (β2-MG) in patients with coronary heart disease (CHD) and left ventricular function and structural changes.Methods A total of 100 patients with CHD from January 2015 to January 2015 in Shaanxi province people's hospital were selected as CHD group, mean age (64.2±11.3) years old. 100 healthy people (age and gender matched) as healthy group, with an average age of (62.1±12.3) years old. Serum levels of Cys-C, β2-MG, left ventricular ejection fraction (LVEF), ventricular septal thickness (IVS), left ventricular mass (LV mass), left ventricular end diastolic diameter (LVEDd), left ventricular systolic (LVESd), left ventricular end-diastolic volume (LVEDv), left ventricular end-systolic volume (LVESv) were analyzed.Results The levels of Cys-C andβ2-MG in CHD group were significantly higher than those in healthy group (P<0.05). The levels of IVS, LV mass, LVEDd, LVESd, LVEDv and LVESv in CHD group were significantly higher than those in healthy group (P<0.05), LVEF level was lower than that in healthy group (P<0.05). The levels of Cys-C and β2-MG in CHD group were significantly correlated with IVS, LV mass, LVEDd, LVESd, LVEDv and LVESv levels (correlation coefficient r was 0.477,0.403,0.377,0.401,0.455,0.462, 0.513, 0.536, 0.428, 0.439, 0.527, 0.589,P<0.05), and there was a significant negative correlation between Cys-C, β2-MG and LVEF (r=-0.544, -0.620,P<0.05).Conclusion The levels of serum Cys-C and β2-MG in CHD patients were significantly improved, and correlated with the left ventricular structure and function of patients.
Keywords：Coronary heart diseaseCystatin Cβ2 microglobulinLeft ventricular function
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 745-747 )