Influence of tirofiban on cardiac arterial blood flow and brain natriuretic peptide in patients with acute ST-segment elevation myocardial infarction
WANG Gui-fang
Abstract：Objective To analyze the influence of tirofiban on cardiac arterial blood flow and brain natriuretic peptide (BNP) in patients with acute ST-segment elevation myocardial infarction (STEMI).Methods STEMI patients (n=122, male 72, female 50, aged from 59 to 70 and average age=65.49±10.03) were chosen from the First People's Hospital of Xinxiang City from Jan. 2013 to Mar. 2016. The patients were divided into observation group (n=58) and control group (n=64) by using random digital table. All patients were given emergency percutaneous coronary intervention (PCI) within 12 h after onset of myocardial infarction. The observation group was given intravenous injection of tirofiban before PCI and intravenous pumping continuously during PCI to the end. The control group was given saline water. All patients were given examination of echocardiogram for detecting left ventricular end-systolic diameter (LVESd), left ventricular end-diastolic inner diameter (LVEDd) and left ventricular ejection fraction (LVEF) before and 1 month after PCI, and level of BNP was detected at the same time. TIMI grading and myocardial perfusion grading were determined after PCI for 3 months, and incidence of major adverse cardiovascular events (MACE) were followed up after PCI for 1 y.Results The difference in patients with grade 3 TIMI had no statistical significance between 2 groups after PCI (P>0.05). The percentage of patients with grade 3 TIMI was significantly higher in observation group than that in control group (87.9%vs. 70.3%,P<0.05) after PCI. LVEF increased in 2 groups, LVEDd decreased in observation group after PCI (allP<0.05). LVEF was significantly higher in observation group than that in control group after PCI (P<0.05). The level of BNP decreased in 2 groups after PCI (allP<0.05). The level of BNP was significantly lower in observation group (178.83± 51.06) pg/mL than that in control group (250.56±48.81) pg/mL after PCI (P<0.05). The incidence of MACE was significantly lower in observation group than that in control group (5.2%vs. 17.2%,P<0.05).Conclusion Tirofiban can improve myocardial perfusion, heart function and BNP level, and reduce incidence of MACE in STEMI patients.
Keywords：TirofibanAcute ST-segment elevation myocardial infarctionBrain natriuretic peptideCoronary intervention therapy
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 724-726 )