Efficacy and safety of atorvastatin in the treatment of elderly patients with ischemic stroke complicated with hyperlipidemia
MENG Wen-chao
GAO Mei-jing
WANG Li-yu
Abstract：Objective To investigate the clinical efficacy and safety of different doses of atorvastatin in elderly patients with ischemic stroke complicated with hyperlipidemia.Method 120 hospitalized patients with ischemic stroke complicated with hyperlipidemia from May 2014 to August 2016. All patients were randomly divided into two groups. Besides treatment with conventional drugs, patients in low dose group were given 10 mg atorvastatin per day, while patients in high dose group were given 20 mg atorvastatin per day. The changes of blood lipid and other indexes were measured before and after treatment for 8 weeks. The clinical efficacy and adverse reaction were compared between the two groups.Results After treatment for 8 weeks, the levels of total cholesterol (TC), low density lipoprotein cholesterol (LDL-C) and high density lipoprotein cholesterol (HDL-C) in the two groups were significantly lower than those before treatment (P<0.05). The total effective rate was 68.3% in the low dose group and 88.3% in the high dose group. The therapeutic effect in the high dose group was better than that in the low dose group (P<0.05). The incidence of adverse reactions was not statistically different between the two groups (P>0.05).Conclusion High-dose atorvastatin is effective in the treatment of elderly patients with ischemic stroke complicated by hyperlipidemia, with good safety.
Keywords：AtorvastatinIschemic strokeHyperlipidemiaElderly
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 700-702 )