The Serum Anion Gap Is Associated with Left Ventricular Systolic Function in Coronary Artery Disease
YANG Shi-wei
ZHOU Yu-jie
ZHAO Ying-xin
LIU Yu-yang
ZHOU Zhi-ming
JIA De-an
HU Bin
SHEN Hua
GAO Fei
MA Qian
HAN Hong-ya
WANG Zhi-jian
Abstract：Objective Aims To evaluate the associations between the serum anion gap (AG) with left ventricular systolic function in coronary artery disease (CAD).Methods From April 2004 to October 2010, a total of 18115 CAD patients were enrolled. All participants underwent clinically indicated coronary angiography and percutaneous coronary intervention. The serum AG was calculated according to the following equation: AG = [Na+ (mmol/L) + K+ (mmol/L)] -[Cl- (mmol/L) + HCO3- (mmol/L)]. Grades of left ventricular systolic function comprised normal (defined as ≥ 50%), preserved (40%-49%), and reduced (< 40%) LVEF.Results A total of 4510 (24.9%) participants had their AG levels greater than 16 mmol/L. And the serum AG was significantly higher in patients with reduced LVEF. The serum AG was independently associated with the grades of left ventricular systolic function. Patients in the 4th quartile of serum AG had a 1.355-fold increased risk of worse left ventricular systolic function (P<0.001). This association was robust, even after adjustment for all confounders (OR: 1.158,P=0.049). After excluding participants with eGFR <60 ml/min/1.73 m2, increased AG was still associated with worse left ventricular systolic function.Conclusion In this large population-based study, our findings reveal a high percentage of increased serum AG in CAD and higher AG values in CAD comorbidited with worse left ventricular systolic function.
Keywords：Anion gapCoronary artery diseaseLeft ventricular systolic function
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 663-666,670 )