Anti-myocardial fibrosis effect of Luofengning Granules Ⅱ: a discussion based on theory of internal stirring of collateral wind
YANG Xue-qing
WANG Xian
Abstract：Objective To observe the influence of Luofengning Granules Ⅱ (LG Ⅱ) on biomarkers of myocardial fibrosis in patients with cardiorenal syndrome (CRS), and explore its mechanism.Methods CRS patients (n=120, male 63, female 57, aged from 35 to 85 and average age=70.36±10.34) were chosen from the Department of Cardiovascular Diseases in the First Clinical Medical School of Beijing University of Chinese Medicine from Oct. 2013 to Jan. 2015. The courses in CRS patients were from 18 m to 480 m and average course was (129.95±43.29) m. The eligible cases (n=104) were randomly divided into 3 groups: whole LG II group (n=35, treated with routine drugs for heart failure and LG II), Qufeng Granules group (n=36, treated with routine drugs for heart failure and Qufeng Granules) and Western drug group (n=33, treated with routine drugs for heart failure). The therapeutic course was for 2 m. The concentration changes of biomarkers related to myocardial fibrosis, heart and kidney were detected including stromelysin-2 (sST2), galectin-3 (Gal-3), N-terminal pro-brain natriuretic peptide (NT-proBNP), cystatin C (CysC) and cardiac troponin I (cTnI).Results The difference in levels of sST2 and Gal-3 had no statistical significance among 3 groups before treatment (P>0.05). The level of sST2 decreased (P<0.05), and level of Gal-3 had no significant changes (P>0.05) in whole LG II group and Qufeng Granules group after treatment, and difference in level of sST2 had no statistical significance in pairwise comparison among 3 groups (P>0.05). The difference in levels of NT-proBNP and cTnI had no statistical significance in pairwise comparison among 3 groups before treatment (P>0.05). The level of NT-proBNP decreased significantly in whole LG II group (P<0.05), and had no significant changes in Qufeng Granules group and Western drug group after treatment (P>0.05). The level of NT-proBNP was significantly lower in whole LG II group and Qufeng Granules group than that in Western drug group after treatment (allP<0.05). The level of cTnI had no significant changes in 3 groups before and after treatment (P>0.05). The difference in CysC and eGFR had no statistical significance in pairwise comparison among 3 groups before treatment (P>0.05). The level of CysC decreased significantly in whole LG II group (P<0.05) and had no significant changes in Qufeng Granules group and Western drug group (P>0.05) after treatment. The level of CysC was significantly lower in whole LG II group than that in Western drug group and Qufeng Granules group after treatment (allP<0.05). The level of eGFR had no significant changes in 3 groups (P>0.05), and was higher in whole LG II group than that in Qufeng Granules group (P<0.05) after treatment.Conclusion LG II has some influence on myocardial fibrosis and biomarkers related to heart and kidney, and reduces levels of sST2, NT-proBNP and CysC and increases level of eGFR. It is speculated that LG II may play the role of protecting heart and kidney through meliorating and even reversing the process of myocardial fibrosis.
Keywords：Internal stirring of collateral windCardiorenal syndromeLuofengning Granule ⅡMyocardial fibrosis
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 612-617 )