Variation trend of creatine kinase MB and cardiac troponin I in patients with uremia complicated by acute left ventricular failure
ZHAO Jin-bao
SHAN Yi
ZHAO Li
TANG Xian-hua
Abstract：Objective To analyze the change trend of creatine kinase MB (CK-MB) and cardiac troponin I (cTnI) and relationship between them and prognosis in patients with uremia complicated by acute left ventricular failure (ALVF).Methods The patients with uremia (n=130, male 76 and female 54) received maintenance hemodialysis (MHD) were chosen from Chinese PLA Navy General Hospital from Jan. 2014 to Jan. 2015. All patients were divided, according to whether or not having ALVF related to MHD, into ALVF group (n=30) and control group (n=100). The levels of CK-MB, cTnI, serum creatinine (SCr) and blood urea nitrogen (BUN) were detected at different time points after ALVF. The groups were followed up for 1 y for comparing the total mortality and cardiac mortality. The levels of N-terminal pro-brain natriuretic peptide (NT-proBNP) and left ventricular ejection fraction (LVEF) were detected during hospitalization and follow-up period (1 m, 6 m and 12 m after discharged from hospital).Results The levels of CK-MB and cTnI were significantly higher in ALVF group than those in control group at different time points (allP<0.05). CK-MB and cTnI increased slowly to platform phase without significant peak value and descending trend in ALVF group. The difference in levels of SCr and BUN had no statistical significance between 2 groups at different time points (allP>0.05). The level of NT-proBNP was significantly higher in ALVF group than that in control group during hospitalization and after discharge for 1 m, 6 m and 12 m (allP<0.05). The level of LVEF was significantly lower in ALVF group than that in control group during hospitalization (P<0.05), and different in level of LVEF had no statistical significance between 2 group during follow-up period (allP>0.05). The total mortality (60.0%vs. 30%) and cardiac mortality (77.8%vs. 46.7%) were all higher in ALVF group than those in control group (allP<0.05).Conclusion The changes of CK-MB and cTnI are significant and related to prognosis in patients with uremia complicated by ALVF.
Keywords：Creatine kinase MBCardiac troponin IUremiaAcute left heart failure
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 563-565 )