Study on the relationship between postprandial remnant-like particle cholesterol (RLP-C) level and the severity of coronary artery lesion in patients with normal low density lipoprotein cholesterol
LI Yi-min
WANG Zhi
LU Zhi-ping
LI Xiang-yu
CHEN Suo-qin
HUANG Jin
Abstract：Objective To investigate postprandial remnant-like particle cholesterol (RLP-C) level in coronary heart disease (CHD) patients with normal low density lipoprotein cholesterol (LDL-C), and the relationship between RLP-C and the severity of coronary artery lesion.Methods 42 CHD patients with normal LDL-C in Nanjing Chest Hospital were recruited from March 2015 to September 2015 and divided into CHD group and control group according to coronary angiography. The levels of total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol (LDL-C) were measured 4 hours fasting and after breakfast. RLP-C level was calculated by the equation (RLP-C=TC-HDL-C-LDL-C). The Gensini score of coronary artery disease was calculated and the relationship with RLP-C was analyzed.Results There was no significant difference in TG, TC, LDL-C and RLP-C between the two groups (P>0.05). HDL-C in the control group was higher than that in the CHD group, the difference was statistically significant (P<0.05). There was no significant difference in TG, TC and LDL-C between the two groups at 4 hours postprandial (P>0.05). The level of RLP-C in CHD group was higher than that in control group, and HDL-C in control group was higher than that in CHD group (P<0.05). The increase of RLP-C in CHD group was significantly higher than that in control group, and the increase of HDL-C in control group was higher than that in CHD group (P<0.05). The postprandial increase of RLP-C was moderately correlated with the Gensini score (r=0.450,P<0.05).Conclusion RLP-C was a better index for the lipid level and the lipid-associated cardiovascular risk to CHD patients.
Keywords：Remnant-like particle cholesterolPostprandial periodCoronary heart disease
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 467-469 )