Influence factors of cardiovascular and cerebrovascular diseases in elderly and middle-aged patients with new-onset type 2 diabetes mellitus
LIN Shan-shan
SHE Qi-mei
YANG Xue-mei
WANG Jun-shu
TIAN Ying-fang
YANG Jing
Abstract：Objective To compare the influence factors of cardiovascular and cerebrovascular diseases in elderly and middle-aged patients with new-onset type 2 diabetes mellitus (T2DM).Methods The patients (n=470, male 283, female 187 and aged from 40 to 76) were chosen from the Beijing Shijingshan Hospital from Jan. 2012 to Jan. 2016. All patients were divided, according to their ages, into elderly group (n=310, age≥60) and middle-aged group (n=160, 40<age<60). The indexes of blood fat, blood pressure (BP), hipline, waistline, body mass index (BMI), high-sensitivity C-reactive protein (hs-CRP), alamine aminotransferase (ALT), aspartate aminotransferase (AST), serum creatinine (SCr), uric acid (UA), glycated hemoglobin (HbAlc), fasting blood glucose (FBG), insulin resistance index (IRI), islet-B-cell function and glomerular filtration rate (GFR) were compared between 2 groups.Results The level of GFR decreased [(129.77±12.29) mL/mim·1.73 m2vs. (111.18±17.26) mL/mim·1.73 m2] and systolic blood pressure (SBP) increased [(125.54±8.77) mmHgvs. (133.5±7.53) mmHg] in elderly group compared with middle-aged group (allP<0.05). The difference in indexes of blood fat, hipline, waistline, BMI, hs-CRP, ALT, AST, UA, Cr, HbA1c, FBG, IRI and islet-B-cell function had no statistical significance between 2 groups (all P>0.05).Conclusion The level of GFR decreases and SBP increases in elderly patients compared with middle-aged patients. The controls of BP and GFR should be strengthened during the comprehensive treatment for down-regulation of blood sugar and blood fat.
Keywords：New-onset type 2 diabetes mellitusHypertensionGlomerular filtration rate
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 446-448 )