Influence of recombinant human brain natriuretic peptide on ventricular remodeling in patients with acute ST-segment elevation myocardial infarction after emergency PCI
WANG Yan-lin
GAO Shu-xian
ZHANG Lan-fang
WANG Yan-fei
LI Jian-hui
ZHANG Xu
Abstract：Objective To analyze the influence of recombinant human brain natriuretic peptide (rhBNP) on ventricular remodeling in patients with acute ST-segment elevation myocardial infarction (STEMI) after emergency percutaneous coronary intervention (PCI).Methods STEMI patients (n=88, male 73 and female 15) were chosen from the Affiliated Hospital of Hebei University from Mar. 2014 to May 2016. All patients were randomly divided into rhBNP group (n=42) and control group (n=46). There were 3 cases missed in rhBNP group and 2 missed in control group, and finally there were 39 cases in rhBNP group and 44 in control group. All patients in 2 groups were given routine drugs and PCI within 12 h after STEMI onset, and rhBNP group was intravenously given rhBNP. The indexes of left ventricular end-diastolic volume (LVEDV) and left ventricular ejection fraction (LVEF) were detected after PCI for 12 h and 6 m, and △LVEDV% was calculated and △LVEDV≥15% was defined as ventricular remodeling. The patients were followed up for 6 m for recording major adverse cardiovascular events (MACE).Results The value of LVEF was improved after PCI for 6 m compared with that after PCI for 12 h, which was more significant in rhBNP group compared with control group [(54.92±3.78)%vs. (52.77±2.90)%, all P<0.05]. The value of LVEDV decreased in rhBNP group compared with control group after PCI for 6 m (P<0.05). There were 2 patients (5.1%) with left ventricular remodeling in rhBNP group and 15 (34.1%) in control group after PCI for 6 m (P<0.05). After followed up for 6 m, there were 4 patients (10.3%) with rhBNP group and 14 (31.8%) in control group (P<0.05).Conclusion The early application of rhBNP after Emergency PCI can relieve ventricular remodeling and reduce incidence of MACE in patients acute STEMI.
Keywords：Acute myocardial infarctionEmergency percutaneous coronary interventionRecombinant human brain natriuretic peptideVentricular remodeling
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 433-435 )