A long-term follow-up on treatment of senile non-valvular atrial fibrillation with low-intensive warfarin anticoagulation therapy
WU Yun-tao
CHEN Yan-mei
TIAN Guo-xiang
YAO Lu
LIU Li-xin
XIA Chang-quan
ZHANG Feng
LI Xiang
ZHANG Wei
GAO Ying-chun
Abstract：Objective To observe the curative effect and safety of low-intensive warfarin anticoagulation therapy for a long time in elderly patients with non-valvular atrial fibrillation (NVAF).Methods NVAF patients (n=115, male 93 and female 22) were chosen from the Chinese PLA Army General Hospital from Jan. 2007 to Jun. 2009. All patients were divided, according to age, into very elderly group (n=58, age≥80) and elderly group (n=57, aged from 65 to 79). The patients were given the examinations of blood routine, liver and kidney functions, thrombin function and international normalized ratio (INR), and oral warfarin in predose (2.5 mg/d) for low-intensive anticoagulation. The target was that INR was from l.6 to 2.5 and dose of warfarin was regulated according to doses of warfarin. The dose of warfarin accorded with target INR steady and adverse reactions were recorded after follow-up for 5 y.Results After continuous monitoring for 5 y, the difference in doses of warfarin accorded with target INR steady had no statistical significance between 2 groups (P>0.05). The difference in INR had no statistical significance between 2 groups (P>0.05). There was no acute cerebral infarction onset in all patients. The difference in incidence of adverse reactions (17.2%vs. 12.3%) had no statistical significance between 2 groups (P>0.05). Conclusion When INR is comprehensively monitored and controlled from 1.6 to 2.5, warfarin is safe and effective for anticoagulation in elderly patients with NVAF.
Keywords：Non-valvular atrial fibrillationWarfarinInternational normalized ratioSafetyLong-term follow-up
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 430-432 )