Cohort studies on magnesium and cardiovascular disease mortality: a Meta-analysis

ZHANG Li-juan; YU Zhi-min; ZHENG Ya-fen; WANG Zhi-quan

doi:10.3969/j.issn.1674-4055.2017.04.03

Abstract：Objective To review systematically the relationship among magnesium intake, serum magnesium and cardiovascular disease mortality (CDM).Methods The databases of PubMed, CNKI, VIP Database and WanFang Database were retrieved with computer for searching the cohort studies on the relationship among magnesium intake, serum magnesium and CDM from database establishment time to Apr. 29, 2016, and meanwhile the references of included studies were retrieved manually. The literature was screened, data was extracted and quality was reviewed independently by 2 reviewers according to inclusion and exclusion criteria, and Stata12.0 software was used for conducting a Meta-analysis.Results There were totally 14 articles included. The results of Meta-analysis showed as follows: ①The difference in CDM had no statistical significance between highest magnesium intake group and lowest magnesium intake group (RR=0.92, 95%CI:0.77~1.10), which indicated that there was no significant correlation between magnesium intake and CDM. ②The difference in CDM had no statistical significance between highest magnesium intake group and lowest magnesium intake group in male subgroup (RR=1.07, 95%CI:0.97~1.19) and highest magnesium intake group and lowest magnesium intake group in female subgroup (RR=0.84, 95%CI:0.61~1.15). ③The difference in CDM had statistical significance between highest serum magnesium group and lowest serum magnesium group (control group), and CDM decreased significantly in highest serum magnesium group (RR=0.74, 95%CI:0.64~0.88).Conclusion The magnesium intake is not correlated to CDM, which has no difference between male group and female group. The level of serum magnesium is negatively correlated to CDM, and in a certain range, the higher the serum magnesium level, the lower the cardiovascular disease mortality.