Correlation between endothelial specific molecule-1 and coronary artery lesions in patients with acute ST-segment elevation myocardial infarction
QIU Chong-rong
LUO Jun
WU Jia-jian
Abstract：Objective To observe the expression of endothelial specific molecule-1 (ESM-1) in patients with acute ST-segment elevation myocardial infarction (ASTEMI), and investigate the correlation between ESM-1 and Gensini integrals of coronary artery lesions.Methods ASTEMI patients (n=121, male 63, female 58, aged from 35 to 86 and average age=62.30±12.33) were continuously chosen into ASTEMI group from the Department of Cardiology of People's Hospital of Ganzhou City from May 2015 to Apr. 2016, and all patients were given examination of coronary angiography (CAG) and Gensini integrals were calculated. Meanwhile the health controls (n=40, male 20, female 20, aged from 40 to 75 and average age=61.24±13.91) were chosen into control group. The blood samples were collected from 2 groups for detecting peripheral ESM-1 level, and difference in ESM-1 level was compared between 2 groups. The correlation between ESM-1 level and Gensini integrals of coronary artery lesions was analyzed in ASTEMI patients.Results ESM-1 level was higher in ASTEMI group than that in control group [(1.19±0.45) ng/mLvs. (1.03±0.03) ng/mL,P<0.05]. The correlation analysis showed that ESM-1 level was positively correlated to Gensini integrals (r=0.18,P<0.05), and was not significantly correlated to number of lesion vessels (r=0.03,P>0.05) in ASTEMI group.Conclusion ESM-1 level is significantly higher in STEMI patients, and positively correlated to Gensini integrals. ESM-1 is a new type biomarker of endothelial dysfunction, and has some clinical significance for estimating the severity of coronary artery lesions.
Keywords：Acute ST-segment elevation myocardial infarctionEndothelial specific molecule-1Coronary artery lesionsGensini integrals
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 353-355,359 )