Influence of ivabradine on 24-h heart rate, B-type natriuretic peptide and 6-minute walk distance in patients with acute decompensated systolic heart failure
GOU Huai-yu
CHEN Yan-qiu
WU Xiao-ling
Abstract：Objective To investigate the influence of ivabradine on 24-h heart rate (24h HR), B-type natriuretic peptide (BNP) and 6-minute walk distance (6MWD) in patients with acute decompensated systolic heart failure (ADSHF).Methods The patients with ADSHF (n=60, male 31 and female 29) were chosen from the People's Hospital in Yubei District of Chongqing City from Jul. 2015 to Jul. 2016. All patients were randomly divided into control group and ivabradine group (eachn=30). All groups were given routine anti-ADSHF treatment and ivabradine group was additionally given ivabradine orally. The changes of 24h HR, BNP and 6MWD were detected in 2 groups before and 7 d after treatment.Results After treatment for 7 d, BNP level and 6MWD were ameliorated in 2 groups (allP<0.05). After treatment for 7 d, 24h HR [(82.54±10.33) time/minvs. (73.45±12.21) time/min], BNP level [(4326±845) pg/mLvs. (3462±786) pg/mL] and 6MWD [(162.01±57.36) mvs. (198.70 ±56.31) m] were all ameliorated in ivabradine group compared with control group (allP<0.05).Conclusion Ivabradine can significantly decrease 24-h HR and BNP level and increase 6MWD in patients with ADSHF.
Keywords：IvabradineAcute decompensated systolic heart failure24 h heart rateB-type natriuretic peptide6-minute walk distance
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 348-350 )