Level of N-terminal pro-brain natriuretic peptide and ultrasonic characteristics in elderly patients with heart failure with preserved ejection fraction
TIAN Gui-fang
YANG Xiu-ling
DAI Yan-yan
WEI Chang-zheng
REN Zhan-ling
Abstract：Objective To analyze the level of N-terminal pro-brain natriuretic peptide (NT-proBNP) and ultrasonic characteristics in elderly patients with heart failure with preserved ejection fraction (HFpEF).Methods The elderly patients with chronic heart failure (CHF,n=186) were continuously chosen from the Department of Cardiology in the Fourth People's Hospital of Langfang City from Mar. 2013 to May 2016, and then divided into HFpEF group and group of heart failure with reduced ejection fraction (HFrEF group). The data collection, laboratory detection and ultrasonic testing were carried out in 2 groups.Results ①The level of plasma NT-proBNP was lower (P<0.05), and level of total cholesterol (TC) was higher (P<0.05) in HFpEF group than that in HFrEF group. ②The left ventricular end-diastolic inner diameter (LVEDd), left atrial diameter (LAD), left ventricular end-diastolic volume (LVEDV) and E/A ratio of mitral flow spectrum were lower (allP<0.05), and interventricular septal thickness (IVST), left ventricular posterior wall thickness (LVPWT) and left ventricular ejection fraction (LVEF) were higher in HFpEF group than those in HFrEF group (allP<0.05). ③In HFpEF group, the level of plasma NT-proBNP was positively correlated to HYHA classification, LVEDd and LAD (r=0.216,r=0.307,r=0.253, allP<0.05), and negatively correlated to LVEF (r=-0.197,P<0.05).Conclusion The level of plasma NT-proBNP and ultrasonic indicator are closely correlated to severity of HFpEF, and their combined application can provide the important evidence for diagnosis and review of HFpEF.
Keywords：Heart failure with preserved ejection fractionN-terminal pro-brain natriuretic peptideEchocardiogram
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 345-347 )