Correlation among pulse wave velocity, blood pressure and blood pressure variability in patients with hypertension

ZHANG Lei; RUAN Yan-ping; WEI Wan-lin; SUN Zhu; YU Qian; YANG Hua

doi:10.3969/j.issn.1674-4055.2017.03.23

Abstract：Objective To review the correlation among pulse wave velocity (PWV) and indexes of blood pressure variability (BPV) in patients with hypertension.Methods The patients with hypertension (n=50) were chosen from the Department of Cardiology of Jingxi Hospital from Jan. 2015 to Jul. 2015, and all of them were given examinations of 24 h ambulatory blood pressure monitoring (ABPM) and PWV. The indexes of BPV were calculated including standard deviation (SD), coefficient of variation (CV) and time rate of BP variation (BP changes at every min) of 24-h systolic blood pressure (SBP) and diastolic blood pressure (DBP), daytime SBP and DBP and nighttime SBP and SBP.Results The average age was (61.16±8.99) in 50 hypertension patients, and there were 19 male patients (38.0%). The percentage of patients with diabetes was 30.0% and percentage of patients with dyslipidemia was 72.0%. The mean BP was 125.25/76.15 mmHg, and PWV was 7.86 m/s in 24 h. The analysis on indexes of BPV showed that SD and time rate of BP variation of SBP were higher than those of DBP, and CV of DBP was higher than that of SBP. The results of Pearson correlation analysis showed that PWV was positively correlated to 24-h mean SBP (r=0.326,P=0.045), 24-h mean DBP (r=0.486,P=0.002), daytime mean SBP (r=0.324,P=0.047), daytime mean DBP (r=0.496,P=0.002) and nighttime mean DBP (r=0.400,P=0.013) after regulating sex, age, diabetes, dyslipidemia and medication. The correlation between PWV and indexes of BPV was not observed (allP>0.05).Conclusion PWV is positively correlated to 24-h and daytime mean BP, and it is not correlated to indexes of BP.