Investigation and analysis of drug treatment and blood pressure control in hypertensive patients in primary hospital

ZHANG Cai-hong; BAO Yan-jiang; GUO Xue-wei

doi:10.3969/j.issn.1674-4055.2017.03.22

Abstract：Objective To investigate the normative and effective treatment of patients with essential hypertension in primary hospitals.Methods A retrospective analysis was conducted on the use of antihypertensive drugs and blood pressure control in 604 hypertensive patients from January 2013 to December 2015. Antihypertensive drugs are divided into three categories: recommended preparations, traditional preparations, traditional Chinese medicine preparations. Recommended agents include angiotensin converting enzyme inhibitors (ACEI), angiotensin II receptor antagonists (ARB), beta blockers (βRB), calcium channel blockers (CCB) and diuretics (HCTZ); Traditional preparations include: antihypertensive 0, compound reserpine equality; traditional Chinese medicine preparations include: Qinggan Jiangya capsule, Niuhuang Jiangya capsules and so on. The average treatment time was 12.31±5.54 days, after treatment for three consecutive days blood pressure≤140/90 mmHg for blood pressure standards. The average treatment time was 12.31±5.54 days. The blood pressure was considered well controlled if the blood pressure≤140/90 mmHg for three consecutive days after treatment. Compliance rate =number of patients / number of treatment × 100%.Results 604 patients were aged between 40 and 96 years with average age (mean 63.44±10.12 years, including 259 males and 345 females. The mean duration of hypertension was 8.5±8.2 years and the hospitalization period was 10 to 20 days. The systolic blood pressure of the patients decreased from 151.9±15.6 mmHg to 128.5±8.0 mmHg, and the diastolic blood pressure decreased from 91.7 ± 9.8 mmHg to 79.6±4.9 mmHg after treatment. The overall compliance rate was 98.5% for all patients, and the compliance rates were 100%, 99.4%, 97.82% respectively in hypertension patients in level 1, 2 and 3. In the use of drugs, 563 patients (93.2%) selected recommended agents; 31 patients (5.1%) using traditional formulations +recommended preparations; 10 patients (1.6%) using traditional Chinese medicine preparations + recommended agents. In the recommended formulation, the proportions of the single preparation, the two preparations and the three preparations were 54.88%, 40.6% and 4.4%, respectively. 67.6% of the single preparation used was CCB,86.4% of the two preparations used was CCB + ACEI / ARB, 68.0% of the three preparations used was ACEI + ARB+ βRB and 4.0% of the three preparations used was CCB + ACEI + ARB.Conclusions Treatment of hypertension hospitalized patients of primary hospital met the standard, the overall compliance rate was over 98%. More than 93% of the patients used the recommended formulation. The use of single and two formulations met the standard, but some drugs with same mechanism were repeatedly used when using three formulations together, which may be the reason of uncontrolled blood pressure of few patients.