Predictive value of gene expression score (GES) on the degree of coronary artery stenosis in non-diabetic patients
ZHANG Liang
SHI Yu-jie
GAO Peng
ZHANG Shu-li
WANG Zhong-lu
DONG Hong-ling
ZHANG Jian
Abstract：Objective To explore and evaluate the value of peripheral blood gene expression score in predicting the degree of coronary artery stenosis in nondiabetic patients.Methods The in-hospital patients (n=146, including 92 males and 54 females) were chosen from Nov.2015 to Apr.2016. All patients were given examinations of coronary angiography (CAG) and LepCare to validate gene expression score (GES) feasibility (score range -30 to 30) as a new method to evaluate the degree of coronary stenosis and analyze the correlation between a peripheral GES and coronary artery stenosis degree.Results Based on the results of coronary angiography as the gold standard, and when the GES threshold was set at 6 points, the area under the ROC curve (AUC) in patients with coronary artery stenosis ≥50% predicted by LepCare score was 0.869±0.033 (95%CI: 0.803~0.934,P<0.01). The sensitivity was 91.8% and the specificity was 70.8%. The proportion of patients with coronary artery stenosis ≥50%was 0 (0%), 20 (43%), 78 (88%) in the range of -30 to -1, -10 to 10, and the higher the gene expression score, the higher the degree of coronary artery stenosis.Conclusions As a noninvasive method, GES has a high clinical value in predicting the degree of coronary artery stenosis in nondiabetic patients.
Keywords：Genetic testingGene expression scoresNon-diabetic populationCoronary heart diseasePredictive value
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 314-316,320 )