Characteristics of carotid plaque and relationship between them and circulating markers in patients with acute coronary syndrome
MENG Zhu
MEI Shao-ping
LI Mei
SONG Da-lin
Abstract：Objective To investigate the correlation between carotid atherosclerotic plaque and circulating markers including tissue-type plasminogen activator (tPA), soluble CD40 ligand (sCD40L) and soluble P-selectin (sP-selection) in patients with acute coronary syndrome (ACS).Methods ACS patients (n=56) were chosen from the Qingdao University Affiliated Hospital and Qingdao Municipal Hospital from 2015 to 2016, and divided, according to whether they had carotid atherosclerotic plaque or not, into positive group (n=18) and negative group (n=38). The levels of tPA, sCD40L and sP-selectin were detected by using liquid protein chip combining flow cytometry, and positive of carotid plaque and circulating markers were given correlation analysis.Results The level of tPA was significantly lower in positive group than that in negative group [(1359.2±714.6) pg/mLvs. (2052.8 ±1700.4) pg/mL,P<0.05], and levels of sCD40L and sP-selectin had no statistical difference between 2 groups (P>0.05).Conclusion There is a higher correlation between carotid plaque and level of serum tPA in ACS patients.
Keywords：Acute coronary syndromeCarotid plaqueCirculating markers
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 280-282,289 )