Effects of the alprostadil combined with salvianolate on renal function in patients who received PCI
XU Wei-yan
LI Ping
LI Zhi-xiong
ZHAO Yan-mei
WANG Zheng-dong
CHEN Jian
Abstract：Objective To investigate the effect of alprostadil combined with salvianolate on renal function after percutaneous coronary intervention (PCI).Methods 282 patients received PCI were randomly divided into three groups, hydration saline group (group A), alprostadil + hydration group (group B), alprostadil joint salvianolate+ hydration group (group C). The levels of serum urea nitrogen (BUN), serum β2 - microglobulin, serum creatinine (Scr) and the incidence of contrast - induced nephropathy (CIN) were measured and compared before operation, 24 h and 72 h after operation.Results The levels of BUN, serum β2-microglobulin and Scr in group A and B were significantly higher than those before operation (P<0.05). The levels of BUN and serum β2 microglobulin in group C were slightly higher than those before operation (P<0.05), and the increase of Scr was not significant (P>0.05). There was no significant difference in BUN and serum β2-microglobulin and Scr between the two groups at 72 h after operation (P>0.05). The incidence of CIN was 13.8% in group A, 9.6% in group B and 3.2% in group C, and there was no significant difference between group B and group A (P>0.05). There was a significant difference between group C and group A (P<0.05).Conclusion The combination of alprostadil and salvia miltiorrhiza phenolic acid + hydration therapy has a certain preventive effect on the contrast agent nephropathy after PCI.
Keywords：AlprostadilSalvianolateHydration programPercutaneous coronary interventionContrast-induced nephropathy
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 277-279 )