The protective effect and mechanism of total glucosides of paeony on atherosclerosis in rats
WANG Xiao-gang
SUN Xin-xin
WANG Shi-jie
LIU Xia
WANG Su-min
WEI Qing-min
ZHANG Hua-long
HE Lei
ZHANG Juan
Abstract：Objective To investigate the protective effect and mechanism of total glucosides of paeony on atherosclerosis in rats.Methods 120 SD rats were randomly divided into control group, model group, TGP group (50 mg/kg·d), TGP group(100 mg/kg·d), TGP group (200 mg/kg·d) and simvastatin group (1.8 mg/kg·d, SV group), 20 rats in each group. Except the control group, the other groups were treated with high fat diet combined with intraperitoneal injection of vitamin D3 (VD3) to establish SD rat atherosclerosis (AS) model. During the modeling process, the rats were given intragastric administration for 12 weeks. The cardiac quality was measured and the cardiac index (CI) was calculated. The morphological changes of the aorta were observed by H & E staining. The blood lipid monitoring indexes (TC, TG, LDL-C (IL-1β, IL-6, IL-10), serum antioxidant enzymes (SOD, GSH-Px, CAT) and malondialdehyde (MDA) were measured by colorimetry. were measured by colorimetry.Results Compared with the model group, CI in TGP groups were significantly decreased, the aortic disease was significantly improved. The levels of CRP, TNF-α, IL-1β and IL-6 in plasma were significantly decreased (P<0.05), and the levels of TC, TG and LDL-C were significantly decreased; the activity of SOD and CAT in serum was significantly increased and the content of MDA was significantly decreased in the TGP group(100 mg/kg·d) and TGP group(200 mg/kg·d). The content of HDL-C and the activity of GSH-Px in TGP group 200 mg/(kg·d) were significantly increased and the content of IL-10 in plasma was significantly increased (P<0.05,P<0.01). Conclusion TGP has protective effects on atherosclerosis rats, which perhaps related to its effects of reducing cholesterol, improving the body's anti-inflammatory and antioxidant capacity.
Keywords：TGPAtherosclerosisBlood lipidInflammationOxidative stress
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 273-276 )