Relationship between CYP17A1 gene polymorphism and hereditary susceptibility of coronary heart disease
JIA Xue-wen
YU Hai-chu
SUN Gui-xia
HAO Jiao-zhen
HUANG Zu-zhou
LIU Shi-Guo
Abstract：Objective To discuss the relationship between gene polymorphism of CYP17A1 (rs4409766-locus, rs1004467-locus) and hereditary susceptibility of coronary heart disease (CHD).Methods The patients with CHD or without CHD diagnosed by coronary angiography (CAG) were chosen from the Department of Cardiovasology in Medical College of Qingdao University from June 2014 to Feb. 2016. CYP17A1 (rs4409766-locus, rs1004467-locus) was given analysis of single nucleotide polymorphism (SNP) by using real-time fluorescence quantitative polymerase chain reaction (RT-PCR) in CHD group (n=88) and non-CHD group (n=89). The distributions of genotype frequency and allele frequency were compared between 2 groups.Results The genotype distribution of CYP17A1-rs4409766-locus had no difference between CHD group and non-CHD group (P>0.05), but the difference in genotype distributions of CC and CT+TT had statistical significance between 2 groups (P=0.038). The difference in genotype and allele distributions of CYP17A1-rs1004467-locus had statistical significance between 2 groups (P>0.05).Conclusion The gene polymorphism of CYP17A1-rs4409766-locus is correlated to the incidence of CHD.
Keywords：Coronary heart diseaseCYP17A1 geneSingle nucleotide polymorphism
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 187-189,198 )