Correlation between polymorphism of interleukin-6 gene-572C/G and risk of ischemic stroke in Chinese population: a Meta-analysis
XU Yue
WENG Hong
FAN Yuan-teng
Abstract：Objective To discuss the correlation between polymorphism of interleukin-6 (IL-6) gene-572C/G and risk of ischemic stroke (IS) in Chinese population.Methods The databases of PubMed, EMbase, CBM, CNKI and WanFang Database were retrieved with computer for searching the case-control studies on the correlation between polymorphism of IL-6 gene-572C/G and risk of IS in Chinese population up to Dec. 2015. The literature was screened and data was extracted by 2 researchers independently according to inclusion and exclusion criteria, and after quality review on methodology the data was given a Meta-analysis by using Stata 12.0 software. Results There were totally 8 case-control studies including 1870 cases of IS patients and 1915 health controls. The results of Meta-analysis showed that polymorphism of IL-6 gene-572C/G might increase the risk of IS in Chinese population (Gvs. C:OR=1.38, 95%CI: 1.14~1.67; GCvs. CC:OR=1.50, 95%CI: 1.26~1.78; GG+GCvs. CC:OR=1.53, 95%CI: 1.26~1.85). The results of analysis in subgroups grouped according to race showed that the risk of IS was more significant in Han population, and decreased in Uygur population.Conclusion The polymorphism of IL-6 gene-572C/G can increase the risk of IS in Chinese population, especially in Han population. As the quantitative limitation of included studies, the conclusion is needed further verification.
Keywords：Interleukin-6PolymorphismIschemic strokeMeta-analysis
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 145-148 )