Improvement of cardial function of stem cell transplantation in dilated cardiomyopathy: A Meta-analysis
ZHENG Ya-fen
ZHANG Li-juan
WANG Zhi-quan.
Abstract：Objective To systematical evaluate the improvement of cardiac function by stem cell transplantation in dilated cardiomyopathy.Methods Randomized controlled trials (RCTs) of all the bone marrow stem cells in the treatment of dilated cardiomyopathy were searched within PubMed, EMBASE, the Cochrane Library, CNKI, Wanfang Database and VIP Database. The retrieval time was from May 31, 2016. The quality of the included studies was evaluated by two investigators based on the inclusion and exclusion criteria. Meta-analysis was performed using Revman 5.3 and stata 12.0 software.Results A total of 15 trials involving 714 patients were included. The result of Meta-analysis showed that ① There was no difference between transplant group and control group in overall mortality (OR=0.66, 95%CI:0.33~1.29,P=0.22). ② There was no difference between two groups in improvement of left ventricular ejection fraction (LVEF) at 3 months after treatment (SMD=0.42, 95%CI:-0.06~0.90,P=0.08), but the LVEF was increased at 6 months after treatment (SMD=0.56, 95%CI:0.06~1.05, P=0.03). ③ There was no difference between two groups in reduce of left ventricular end-diastolic diameter (LVEDd) at 1 month after treatment (SMD=-0.65, 95%CI:-1.96~0.67,P=0.34), but LVEDd was decreased at 3 months after treatment in transplant group than that in control group (SMD=-1.59, 95%CI:-2.75~-0.43,P=0.007). ④ Result of subgroup analysis showed no difference with respect to LVEF (SMD=1.16, 95%CI:-6.05~8.37,P=0.75), LVEDd (SMD=0.23, 95%CI:-2.73~3.18,P=0.88) and overall mortality (OR=0.35, 95%CI:0.05~2.65,P=0.31) when the number of transplant cells<108. But when the number of transplant cells>108, LVEF was improved (SMD=4.37, 95%CI:2.30~6.45,P<0.00001), and LVEDd was reduced (SMD=-2.25, 95%CI= -3.63~0.86,P=0.001) significantly. There was no difference between two groups in overall mortality (OR=0.73, 95%CI:0.38~1.43 P=0.36).Conclusion Stem cell transplant can improve cardiac function and reconstruct cardiac muscular structure, which are more obvious in long-term observation. Transplant cell>108 may be more beneficial.
Keywords：Stem cell transplantationDilated cardiomyopathyMeta-analysis
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 140-144 )