Influence of Hcy-lowering therapy on level of inflammatory factors in patients with coronary heart disease after percutaneous coronary intervention
WANG Li-juan
FAN Hua
BAI Hong-xing
Abstract：Objective To study the influence of homocysteine (Hcy)-lowering therapy on level of serum inflammatory factors in patients with coronary heart disease (CHD) after percutaneous coronary intervention (PCI).Methods CHD patients (n=180) undergone PCI were chosen from the People’s Hospital of Yan’an City from Jan. 2013 to Dec. 2015, and then divided randomly into observation group and control group (eachn=90). The control group was treated with routine drugs, clopidogrel, aspirin, β-receptor blocker and statins, and the observation group was additionally given Vitamin B6, Vitamin B12 and folic acid for lowering Hcy for half year. The differences in levels of inflammatory factors, serum Hcy, soluble intercellular adhesion molecule-1 (ICAM-1), procalcitonin and N-terminal pro-brain natriuretic peptide (NT-proBNP) were compared between 2 groups. Results The differences in general data including sex, age, body mass index, complications, lesion vessels and CHD types had no statistical significance between 2 groups (P>0.05). After treatment for half year, the levels of serum Hcy, interleukin-6, C-reactive protein, soluble ICAM-1, procalcitonin and NT-proBNP decreased significantly in observation group (P<0.05), and were significantly lower than those in control group (P<0.05).Conclusion The Hcy-lowering therapy can effectively reduce the level of serum Hcy, protect myocardial function and relieve systemic inflammatory responses in patients with CHD after PCI.
Keywords：HomocysteineCoronary heart diseaseInterventional therapyInflammatory factors
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 78-80 )