Influence of different lipid regulation schemes on hepatic and renal functions and immunoreaction related factors in rat model of arteriosclerosis
LI Jun
XUE Yang
SHEN Jing
LIU Ming
ZHANG Jing
Abstract：Objective To discuss the influence of different lipid regulation schemes on hepatic and renal functions and immunoreactions related factors in rat model of arteriosclerosis.Methods Health male Wistar rats (n=42, aged 6 w and weighed 210 g±10 g) were chosen, and divided into 5 groups: normal control group (N group), high-lipid model group (C group), low-dose simvatatin group (10 mg/kg·d, S group), high-dose simvatatin group (20 mg/kg·d, SH group), and low-dose simvatatin+ezetimibe group (10 mg/kg·d+5 mg/kg·d, SE group). All medication groups were orally given corresponding drugs for 4 w. The indexes of blood fat and hepatic and renal functions, and levels of interferon-r (IFN-r) and interleukin-4 (IL-4) were detected before and after medication. Results The levels of triglyceride (TG), total cholesterol (TC), low-density lipoprotein-cholesterol (LDL-C), alanine aminotransferase (ALT) and aspertate aminotransferase (AST) decreased significantly in S group, SH group and SE group compared with C group, which was more significant in SE group. The levels of blood urea nitrogen (BUN), uric acid (UA) and urine protein (U-pro) decreased significantly in S group, SH group and SE group, and creatinine clearance rate (CCr) increased compared with C group, which was more significant in SH group. The level of serum IFN-r increased in C group, and decreased in SH group compared with S group and SE group (P<0.01). The level of serum IFN-r was positively correlated to levels of TG, TC and LDL-C (P<0.05), and was negatively correlated to high-density lipoprotein-cholesterol (HDL-C,P<0.05).Conclusion The lipid-lowering effect of low-dose simvatatin combining ezetimibe is significant, which can ameliorate abnormal hepatic function induced by hyperlipidemia, and high-dose simvatatin can effectively protect renal function. The level of serum IFN-r is definitely correlated to level of blood fat, and high-dose simvatatin can significantly decrease the level of serum IFN-r in rats.
Keywords：ArteriosclerosisSimvatatinEzetimibeHepatic and renal functionsImmune factors
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 66-70 )