Influence of sodium tanshinoneⅡA sulfonate on oxidative stress level in patients with acute coronary syndrome

LIN Chuan-huan; LIU Yi-jun; GU Xin

doi:10.3969/j.issn.1674-4055.2017.01.17

Abstract：Objective To study the influence of sodium tanshinone ⅡA sulfonate (ST-ⅡA-S) on oxidative stress level in patients with acute coronary syndrome (ACS).Methods ACS patients (n=98) were chosen from the Intensive Care Unit of the Third People’s Hospital of Huizhou City from Jan. 2015 to Dec. 2015, and divided randomly into ST-ⅡA-S group and control group (eachn=49). The control group was given percutaneous coronary intervention (PCI), anti-platelet therapy, β-receptor blocker, nitrates and statins, and ST-ⅡA-S group was given ST-ⅡA-S and the same therapies as control group. The indexes of total cholesterol (TC), triglyceride (TG), high-density lipoprotein-cholesterol (HDL-C, low-density lipoprotein-cholesterol (LDL-C), high-sensitivity C-reactive protein (hs-CRP), tumor necrosis factor-α (TNF-α), matrix metalloproteinase-9 (MMP-9), homocysteine (Hcy), lipid peroxide (LPO), malondialdehyde (MDA) and superoxide dismutase (SOD), and effective rate and adverse reactions were observed in 2 groups before and 14 d after treatment.Results The difference in levels of TC, TG, HDL-C and LDL-C had no statistical significance between 2 groups 14 d after treatment (P>0.05). The levels of hs-CRP, TNF-α, MMP-9 and Hcy were significantly lower in ST-IIA-S than those in control group (P<0.05). The levels of LPO and MDA were significantly lower, and SOD level was significantly higher in ST-IIA-S group than those in control group 14 d after treatment (allP<0.05). The total effective rate was 91.84% in ST-IIA-S group and 77.55% in control group (P<0.05), and there were no significant adverse reactions observed in 2 groups during treatment period.Conclusion ST-IIA-S therapy can effectively relieve the inflammatory response, reduce oxidative stress level and has significant clinical efficacy in treatment of ACS.