The relationship between dynamic pulse pressure and early renal function in diabetes mellitus patients with normal blood pressure
SHEN Jun
YANG Tian
CHEN Xiao-lin
YUAN shuang-shuang
LIU Xing
Abstract：Objective To investigate the relationship between dynamic pulse pressure and urinary albumin creatinine ratio (UACR) in diabetes mellitus (DM) patients with normal blood pressure.Methods A total of 121 patients with DM qualified were enrolled. The 121 patients were divided into A group (PP<50 mmHg,n=42), B (50 mmHg≤PP≤70 mmHg,n=48) and C group (PP>70 mmHg,n=31) according to 24-hour dynamic pulse pressure (PP) levels. Results UACR was used as an indicator of early renal impairment to discuss the relationship between dynamic PP and UACR by investigating UACR and dynamic PP levels in each group. Among three groups, there were no statistically significant differences (P>0.05) in the traditional indicators of kidney function, such as serum creatinine (Scr), blood urea nitrogen (BUN), uric acid (UA). There were statistically significant differences in the early indicators of kidney function, such as UACR (P<0.05).Result of Pearson correlation analysis showed that UACR were positively correlated with age, consulting room diastolic blood pressure (DBP), 24-hour mean PP, day mean PP, night mean PP (P<0.05), but there was no close correlation (P>0.05) with consulting room systolic blood pressure (SBP), total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), fasting blood glucose (FBG), haemoglobinA1C (HbA1c). Result of multivariate regression analysis indicated that 24 h pulse pressure (24h mPP), mean pulse pressure at night (mPP) were impact factors of UACR (P<0.05).Conclusion In DM patients with normal blood pressure, UACR (i.e. early renal function index) was significantly increased along with the increase of pulse pressure, suggesting that dynamic pulse pressure is correlated with early diabetic nephropathy (DN).
Keywords：Diabetes mellitusDynamic pulse pressureEarly kidney function
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 53-55 )