The correlation between metabolic syndrome and coronary artery lesions in patients with coronary heart disease
LI Yao-hua
XIE Ping
Abstract：Objective To investigate the correlation between metabolic syndrome (MS) and characteristics of coronary artery lesions in patients with coronary heart disease (CHD).Methods From January 2014 to January 2015, 434 consecutive patients who diagnosed as CHD by coronary angiography were enrolled, they were divided into MS group and non-MS (NMS) group. The consequences of coronary angiography in two groups were evaluated according to the number of lesions, morphology of lesions and Gensini score. The correlation between MS components, Gensini score and severity of coronary artery were analyzed.Results Patient's age, waist circumference, hip circumference, body weight, body mass index (BMI), systolic blood pressure (SBP), diastolic blood pressure (DBP), fasting plasma glucose (FPG), glycosylated hemoglobin (HbA1c), total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol LDL-C), uric acid (UA), high-sensitivity C-reactive protein (hs-CRP), homocysteine (Hcy), incidence of double or multiple lesions, cases of complex lesions and Gensini score were higher in MS group than that in NMS group, the differences were statistically significant (P<0.01 or 0.05);high-density lipoprotein cholesterol (HDL-C) and total bilirubin (TBIL) were lower in MS group than that in NMS group, the differences were statistically significant (P<0.05). Result of Pearson correlation analysis showed that FPG, HbA1c, SBP, DBP, TG, TC, LDL-C, UA were all positively correlated with the Gensini score (r=0.090-0.278, P<0.05), HDL-C and TBIL were negatively correlated with Gensini score (r=-0.120 and -0.097,P<0.05). Hcy and hs-CRP were not correlated with Gensini scores (r=0.090 and 0.098,P>0.05). Result of logistic regression analysis showed that the age, BMI, SBP, HbA1c and TC were the independent risk factors of the severity of coronary lesions (OR>1,P<0.05); HDL-C and TBIL were the protective factors of the severity of coronary lesions (OR<1, P<0.05).Conclusion MS patients have higher CHD risk factors, more complex and severe coronary artery lesions, taking effective measures to control the glucose, lipid, pressure levels and other risk factors of MS are particularly important for the prevention and treatment of CHD.
Keywords：Metabolic syndromeCoronary heart diseaseCoronary artery lesionGensini score
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 41-45 )