Curative effect and safety of Maiguanfukang Pian in treatment of lower limb arteriosclerosis obliterans:a systematic review

WANG Xue-jun; GUO Jia-long; PEI Bin; ZHAO Bao-ming; HONG Yi-long; ZENG Xian-tao

doi:10.3969/j.issn.1674-4055.2017.01.06

Abstract：Objective To review the curative effect and safety of Maiguanfukang Pian in treatment of lower limb arteriosclerosis obliterans (LASO).Methods The databases of PubMed, EMbase, Cochrane Library (2016.2), CBM, CNKI, WanFang Data and VIP Database were retrieved for collecting clinical trials related to treatment of LASO with Maiguanfukang Pian up to Mar. 2016. The literature was screened and data was extracted by 2 reviewers independently, and the forest plot was drawn by using ReMan 5.3 software and the results of included trials were reviewed systematically.Results There were totally 4 trials included involving 317 patients. The results showed that curative effect of Maiguanfukang Pian was superior to that of Fufangdanshen Pian (total effective rate:RR=1.27, 95%CI: 1.05~1.54), and was the same as that of Tongsaimai Pian (RR=1.25, 95%CI: 0.99~1.58) and Hanjing Tang combining Slight sweating method (RR=0.83, 95%CI: 0.66~1.04). The curative effect of Maiguanfukang Pian combining alprostadil was superior to that of single alprostadil (RR=1.29, 95%CI: 1.05~1.60). Maiguanfukang Pian single or combining with other drugs could significantly relieve clinical symptoms and signs, and improve hemorrheology and ankle-brachial index without severe adverse reactions compared with other therapeutic schedules.Conclusion The current evidence shows that Maiguanfukang Pian single or combining with other drugs can significantly relieve clinical symptoms and signs in with patients LASO. As the limitation of quantity and quality of included trials, further relevant studies are needed to confirm the conclusion.