The value of serum N-terminal pro-brain natriuretic peptide in evaluation of prognosis of chronic heart failure
SONG Wei
HUANG Guo-yong
FANG Yong
CHEN Kai-hong
LI Wei-guo
LIAO Ying
Abstract：Objectives To investigate the value of N-terminal pro-brain natriuretic peptide (NT-proBNP) in prognosis of patients with Chronic heart failure (CHF).Methods Eighty CHF patients were selected from January 2012 to December 2013 in Department of Cardiology, Longyan First Hospital Affiliated to Fujian Medical University, and divided into low level group (n=26), medium level group (n=24), and high level group (n=30) based on level of NT-proBNP at the day of admission. All three groups received conventional treatment. Serum NT-proBNP level was compared before and after treatment in three groups and in patients with different heart functional class. Correlation of serum NT-pro BNP level and cardiac function classification were analyzed. The relationship between NT-proBNP levels with rehospitalization and mortality was analyzed in three groups during the follow-up period.Results After treatment, the levels of NT-proBNP were significantly decreased in the three groups and the patients with different grades of cardiac function. The difference was statistically significant (P<0.05). There was a significant positive correlation between NT-proBNP and cardiac function (r=0.71,P<0.001). During the follow-up period, the re-hospitalization rates were 7.69%, 25.00% and 36.67% in the low, medium and high-level groups, respectively, with mortality rates of 3.85%, 20.83% and 40.00%, respectively. The rates of rehospitalization and mortality in the three groups were statistically significant (P<0.05). There was a significant positive correlation between serum NT-proBNP and CHF re-hospitalization rate (r=0.54,P<0.001) and mortality (r=0.47,P<0.001). Conclusion The serum NT-proBNP level was positively correlated with CHF patients' cardiac function grade, re-hospitalization rate and mortality rate. By monitoring serum NT-proBNP level, we could not only grasp the severity of CHF, but also accurately evaluate the prognosis of patients.
Keywords：N-terminal brain natriuretic peptide precursorChronic heart failureEvaluation of prognosisApplication value
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1501-1503,1507 )