Efficacy and safety of pitavastatin combined with ezetimibe in treatment of coronary heart disease with type 2 diabetes mellitus in elderly patients
HU Guang-hui
WU Yun-tao
ZHAO Bao-gang
YAO Lu
CHEN Yan-mei
LIU Li-xin
XIA Chang-quan
ZHANG Wei
Abstract：Objective To observe the efficacy and safety of Pitavastatin calcium combined with Ezetimibe in the treatment of coronary heart disease with type 2 diabetes mellitus in elderly patients.Methods 115 elderly patients with coronary heart disease and type 2 diabetes mellitus hospitalized in PLA Army General Hospital from January 2015 to January 2016 were enrolled in the study. 60 patients as observation group [low-density lipoprotein cholesterol (LDL-C)≥1.8 mmol/L] received oral Pitavastatin calcium 2 mg + ezetimibe 10 mg every night before going to bed; and 55 patients as control group [low-density lipoprotein cholesterol (LDL-C) <1.8 mmol/L] received oral Pitavastatin calcium 2 mg every night before going to bed. The levels of total cholesterol(TC), triglyceride(TG), high density lipoprotein(HDL-C), low density lipoprotein (LDL-C), creatine kinase (CPK) and the liver and kidney function were measured before treatment, 4 weeks after treatment, 8 weeks after treatment and 6 months after treatment.Results There was no significant difference in TC, LDL-C and HDL-C before and after treatment (P>0.05). The levels of TC and LDL-C in treatment group were significantly lower than those before treatment (P<0.05). There was no significant difference in HDL-C between the two groups before and after treatment (P>0.05). After treatment, the liver and kidney function and CPK levels were not significantly changed.Conclusions Efficacy and safety of Pitavastatin calcium combined with Ezetimibe in elderly men with coronary heart disease and type 2 diabetes mellitus were good.
Keywords：Coronary heart diseasePitavastatinEzetimibeType 2 Diabetes MellitusElderly
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1466-1469 )