Polymorphism of thrombospondin-1 gene in patients with acute coronary syndrome
GAO Lei
HE Guo-ping
QIAN Yi-chao
QI Chuan-ping
Abstract：Objective To analyze the correlation between polymorphism of the thrombospondin-1 (TSP-1) gene A2210G (N700S) and acute coronary syndrome (ACS) in the Chinese population.Methods A case-control study was conducted. By polymerase chain reaction and restriction fragment length polymorphism analysis, the TSP-1 A2210G polymorphism was analyzed in 412 patients with ACS (ACS group) and 337 control subjects free from coronary artery disease (control group) from Affiliated Wujin Hospital of Jiangsu University between June 2005 and November 2010.Results The frequencies of AG genotype were 1.5% and 0.6% in ACS group and control group, respectively (P=0.43). None of the homozygotes were detected for the G allele. The prevalence of the G allele was not significantly different between ACS group and control group (0.7%vs. 0.3%,P=0.43). Result of multivariate logistic regression analysis showed that AG genotype of TSP-1 gene had no significant correlation with ACS (OR=2.36;95%CI:0.46~12.48;P=0.46).Conclusion The TSP-1 N700S variant shows a low prevalence in the Chinese population and fails to associate with an altered risk of ACS.
Keywords：ThrombospondinGenetic polymorphismAcute coronary syndrome
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 1449-1451 )