Association between basal cystatin C and contrast-induced acute kidney injury
LIANG Deng-pan
ZHOU Peng
WANG Qiu-lin
CAI Guo-cai
LI Lu
JIANG Li-cheng
LI Wen-zhang
YANG Zhen
PU Jing
Abstract：Objective To investigate the relationship between basal serum cystatin C levels and contrast-induced acute renal injury (CI-AKI) in patients with suspected coronary artery disease before undergoing coronary angiography and / or percutaneous coronary intervention.Methods A total of 1152 patients undergoing coronary angiography and / or percutaneous coronary intervention were enrolled, and divided into three groups according to the tertile of basal serum cystatin C levels (group T1: ≤0.95mg/L,n=362; group T2: 0.95-1.08mg/L,n=363; group T3:≥1.08mg/L,n=427). Multivariate logistic regression analysis was used to analyze the independent risk factors for CI-AKI.Results There were 362 patients in group T1 including 137 males (37.8%) with mean age (61.9±7.2), 363 patients group T2 including 152 males (41.9%) with mean age (62.3±7.3), and 427 patients in group T3 including 190 males (44.5%) with mean age (63.1±7.2). Among all of the study patients, 73 cases (6.3%) developed CI-AKI. Baseline cystatin C was higher in CI-AKI patients than in Non-CI-AKI patients [(1.24±0.29) mg/Lvs. (1.06±0.37) mg/L,P<0.001]. After adjustment for age, gender, creatinine, uric acid, diabetes mellitus, contrast medium volume, risk of CI-AKI was significantly higher in group T3 than in group T1 (OR: 2.890, 95%CI: 1.205~6.929,P=0.017). Conclusion Elevated basal serum cystatin C levels may increase the risk of CI-AKI before coronary angiography and / or percutaneous coronary intervention.
Keywords：Contrast-induced acute kidney injuryCystatin CRenal insufficiency
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1445-1448 )