A Meta-analysis on curative effect of Danshen Injection combining conventional Western drugs on angina pectoris

LI Meng-si; HE Lei; LI Yao-yao; ZHAO Tian-ya; GAO Ping

doi:10.3969/j.issn.1674-4055.2016.12.04

Abstract：Objective To review systematically the efficacy of Danshen Injection combining conventional Western drugs in treatment of angina pectoris.Methods The databases of PubMed, Cochrane Library, EMbase, Sino-Med, Google Scholar, WanFang Database and CNKI were retrieved for searching randomized controlled trails (RCT) about the treatment of angina pectoris with Danshen Injection combining conventional Western drugs published from Jan. 2000 to Jan. 2016, and the eligible literature to inclusive standard were screened. The curative effect on symptoms of angina pectoris and curative effect showed by electrocardiogram (ECG) were taken as effect indexes, and a Meta-analysis was conducted by using RevMan 5.0 software and Stata 12.0 software. The methodological quality of inclusive literature was reviewed by using revised Jadad scale.Results There were totally 1493 literature retrieved and finally 12 RCT included involved 1194 patients. Compared with control group (with only conventional Western drugs), the curative effect was significantly improved (OR=4.16, 95%CI: 2.97~5.84,I2=0%,P<0.001), and ECG manifestations were much better (OR=2.60, 95%CI: 1.87~3.61,I2=0%,P=0.004) in treatment group (with Danshen Injection combining conventional Western drugs. There were only 2 literature reported adverse reactions, and treatment group and control group had no significant difference.Conclusion Danshen Injection combining conventional Western drugs can improve the curative effect and ECG manifestations in the treatment of angina pectoris. As the samples are less and quality is lower in this study, more large-sample double-blinded RCT with stricter design and higher quality are needed for verifying the curative effect.