Evaluation the early effects of different calcium concentration on carotid artery elasticity and deformation capability in maintenance hemodialysis patients by QAS and X-strain technique

XING Yu-wei; ZHENG Min; LI Shuo; HOU Li-fang; SUN Su-li

doi:10.3969/j.issn.1674-4055.2016.11.25

Abstract：Objective To evaluate the early effects of different calcium concentration on carotid artery elasticity and deformation capability in maintenance hemodialysis patients by quantitative artery stiffness (QAS) and X-strain technique.Methods 60 calcium dialysis patients were Randomly divided into two groups according to the dialysate concentrations: low calcium group (1.25 mmol/L) and standard calcium group (1.50 mmol/L). Each group had 30 patients. Biochemical indexes including but not limited to calcium, phosphorus, parathyroid hormone (PTH) were measured. intima-media thickness (IMT), resistance index (RI) and so on were measured by carotid artery ultrasonography. Compliance coefficient (CC), distention coefficient (DC), stiffness parameter α, stiffness parameterβ, pulse wave velocity (PWV), augmentation index (AIx), circumferential strain (Cs) and circumferential strain rate (Csr) were measured by QAS and X-strain and compared between two groups.Results ①At 6 month after the hemodialysis, calcium, phosphorus and calcium-phosphorus product of the low calcium group were significantly decreased than that of the standard calcium group, while PTH was increased (P<0.05). ②At 6 month after the hemodialysis, the values of IMT, RI, α, β, PWV and AIx of the low calcium group were decreased than that of the standard calcium group, while the values of Cs, Csr were increased (P<0.05). ③There is a correlation among IMT,α, β, PWV, Cs and Csr. ④Calcium has a significant impact on the carotid artery elasticity.Conclusion QAS and X-strain technology can early detect the effects of different calcium dialysate on carotid elasticity and deformation capacity in maintenance hemodialysis patients. It has important implications for clinical timely adjustment of dialysis programs, as well as prevention.