Protective effect of Qishenyiqi Gutta Pills preconditioning on myocardium in elderly patients with valve replacement
CUI Zhen-tian
WEI Wan-lin
LIU Jian-ping
JIA Zhong-yu
SHI Yang
Abstract：Objective To observe the influence of Qishenyiqi Gutta Pills preconditioning on myocardial protection in patients with open-heart valve replacement.Methods The patients (n=120) accorded with diagnosis and inclusive criteria and undergone open-heart mitral valve and/or aortic valve replacements were chosen from the Chinese PLA Army General Hospital from May 2012 to May 2013, and randomly divided into observation group and control group (eachn=60). The control group was given placebo (as same as Qishenyiqi Gutta Pills in color and smell) 0.5 g/time and 3 times a day, and 0.5 h after meal for 7 d continuously on the base of conventional cardiotonic and diuretic therapies before the surgery. The observation group was given Qishenyiqi Gutta Pills 0.5 g/time and 3 times a day, and 0.5 h after meal for 7 d continuously on the base of the same therapies in the control group before the surgery. The levels of creatine phosphokinase MB (CK-MB) and cardiac troponin I (cTnI) were detected at the time points of before anesthesia (T0), 12 h after the surgery (T12) and 24 h after the surgery (T24). The time of cardiopulmonary bypass (CPB), assisted circulation time, time of ascending aortic occlusion, heart auto-rebeating situation after opening ascending aorta, dopamine dosage after stopping CPB, incidence of arrhythmia and stay time in ICU were recorded in 2 groups.Results There were 28 male cases and 32 female cases, and average age=(55.20 ±9.20) in observation group, and 32 male cases and 20 female cases, and average age=(57.1±10.4) in control group. The differences in disease, surgery, age, gender, weight, preoperative cardiac function grading, anesthesia method, medication during surgery and postoperative medication had no statistical significance between 2 groups (P>0.05). The difference in CPB time, assisted circulation time and time of aortic occlusion had no statistical significance between 2 groups (P>0.05). The incidence of arrhythmia was lower in observation group than that in control group and the type of arrhythmia was paroxysmal atrial fibrillation, but there was no significantly statistical difference between 2 group (P>0.05). The average dopamine dosage, heart auto-rebeating situation after openingascending aorta and stay time in ICU were superior in observation group to those in control group, and levels of cTnI and CK-MB were lower in observation group than those in control group at 3 time points (P<0.05).Conclusion Qishenyiqi Gutta Pills used based on preoperative conventional therapies can reduce the overflow of myocardial enzymes, protect cardiomyocytes injured by ischemic reperfusion, and improve postoperative heart function and recover in patients with heart valve disease.
Keywords：Qishenyiqi Gutta PillsMedical preconditioningRheumatic heart diseaseValve replacementMyocardial protection
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1337-1340 )