Level changes of thrombus precursor protein and P-selectin in patients with non-valvu1ar atrial fibrillation
ZHAO Hong-li
LIU Li-min
ZHANG Xiao-dan
ZHOU Jia-meng
WANG Xiao-xi
Abstract：Objective To analyze the level changes of thrombus precursor protein (TpP) and P-selectin (Ps) in patients with non-valvu1ar atrial fibrillation (NVAF).Methods NVAF patients (n=206, male 132, female 74 and aged from 39 to 79) were chosen and included into NVAF group from the Department of Cardiovascular Diseases of the Second Affiliated Hospital of Shenyang Medical College from May 2014 to Oct. 2015. The patients with coronary heart disease (CHD,n=78) and dilated cardiomyopathy (DCM,n=2) were chosen and included into control group (n=80). NVAF group was divided, according to CHADS2 scores, into CHADS2≥2 group (n=87) and CHADS2<2 group (n=119). There were 87 cases in NVAF group with definite AF attack time and they were divided into ≥48 h group (n=59) and <48 h group (n=28). In addition, there were 102 cases in NVAF group with definite AF types and they were divided into sustained AF group (n=66) and paroxysmal AF group (n=36). The baseline materials were collected from the patients, including sex, age, left atrial diameter (LAD), left ventricular ejection fraction (LVEF), duration and types of AF and CHADS2 scores. The levels of Ps and TpP were detected by using enzyme-linked immunosorbent assay (ELISA).Results The comparison in compositions of age and sex, ratio of patients with complicating diseases, LAD and LVEF had no statistical significance between NVAF group and control group (allP>0.05). The levels of TpP and Ps increased a little in NVAF group compared with control group but the difference was not statistically significant (all P>0.05). Compared with CHADS2<2 group, age and ratio of patients with complicating hypertension and diabetes increased, and levels of TpP and Ps increased significantly in CHADS2≥2 group (allP<0.05). The comparison in compositions of age and sex, ratio of patients with complicating diseases, LAD and LVEF had no statistical significance between ≥48 h group and <48 h group (allP>0.05). The levels of TpP and Ps increased a little in ≥48 h group compared with <48 h group but the difference was not statistically significant (allP>0.05). The comparison in compositions of age and sex, ratio of patients with hypertension, LAD and LVEF had no statistical significance betweensustained AF group and paroxysmal AF group (allP>0.05). The ratio of patients with complicating diabetes and levels of TpP and Ps were higher in sustained AF group than those in paroxysmal AF group but the difference was not statistically significant (allP>0.05).Conclusion The levels of TpP and Ps are higher in NVAF patients with CHADS2≥2. Monitoring the levels of TpP and Ps is beneficial to identifying stroke risk.
Keywords：Thrombus precursor proteinP-selectinAtrial fibrillation
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 1326-1328 )