Relationship between level of serum visfatin and central aortic systolic blood pressure in overweight or obese young college students

LIAO Ming-yuan; TIAN Jian-wei; WANG Xin-yan; XU Bo; YU Xin-ya; ZHANG Na; ZHANG Ya-hua

doi:10.3969/j.issn.1674-4055.2016.11.11

Abstract：Objective To detect the level of serum visfatin in overweight or obese young college students in China, and investigate the relationship between it and central aortic systolic blood pressure (CSBP).Methods The overweight or obese young college students (n=148 and aged from 17 to 23) were chosen from the central campus of Xi’an Technological University, and among them 45 students with hypertension were included in hypertension group and 103 with normal blood pressure (BP) were included in control group. CSBP was detected by using non-invasive SphygmoCor aortic pulse analyzer, and peripheral blood pressure was measured by using mercury sphygmomanometer. The level of serum visfatin was detected by using enzyme-linked immunosorbent assay (ELISA), and the relationship among visfatin, CSBP, peripheral brachial artery systolic pressure (BASP), peripheral brachial artery diastolic pressure (BADP) and brachial artery mean arterial pressure (BAMAP) was analyzed.Results CSBP, BASP, BADP and BAMAP were all higher in hypertension group than those in control group (allP<0.001). The level of serum visfatin was higher in hypertension group than that in control group [(227.33 ±30.93) μg/Lvs. (201.58±34.03) μg/L,P<0.001]. The level of serum visfatin was positively correlated to CSBP, BASP, BADP and BAMAP (r=0.498, 0.489, 0.414, 0.460, allP<0.001).Conclusion The hypertensive patients in overweight or obese young college students have higher level of serum visfatin compared with those with normal BP. The level of serum visfatin is positively correlated to CSBP and peripheral BP, which indicates that visfatin may participate the occurrence and development of obesity-related hypertension in young students.